Optimizing vaccine distribution networks in low and middle-income countries

Vaccination has been proven to be the most effective method prevent infectious diseases. However, there are still millions of children in low and middle-income countries who not covered by routine vaccines remain at risk. The World Health Organization – Expanded Programme on Immunization (WHO-EPI) was designed provide universal childhood vaccine access for across world this work, we address design distribution network WHO-EPI vaccines. In particular, formulate problem as a mixed integer program (MIP) present new algorithm typical problems that too large solved using commercial MIP software. We test data derived from four different sub-Saharan Africa show is able obtain high-quality solutions even largest within few minutes.